Document Detail


Anaphylactoid response to Optison(R) and its effects on pulmonary function in two dogs.
MedLine Citation:
PMID:  15585961     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injection alone. Gas exchange was maintained by mechanical ventilation and 5 cm H(2)O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison, and (2) availability of access to the airway in addition to emergency agents may be prudent preventive measures when Optison is used in animals to enhance echocardiographic imaging.
Authors:
Yoshiki Yamaya; Kyuichi Niizeki; Jeannie Kim; Pauline Entin; Harrieth Wagner; Peter D Wagner
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  66     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-08     Completed Date:  2005-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1429-32     Citation Subset:  IM    
Affiliation:
Division of Physiology, Department of Medicine, University of California, USA.
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MeSH Terms
Descriptor/Qualifier:
Albumins / adverse effects*
Anaphylaxis / chemically induced,  physiopathology,  veterinary*
Animals
Contrast Media / adverse effects*
Dog Diseases / chemically induced*,  physiopathology
Dogs
Fluorocarbons / adverse effects*
Hemodynamics / drug effects
Male
Pulmonary Gas Exchange / drug effects
Vascular Resistance / drug effects
Grant Support
ID/Acronym/Agency:
5 T32 HL07022-25/HL/NHLBI NIH HHS; HL17731/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons

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