Document Detail

Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke.
MedLine Citation:
PMID:  10813008     Owner:  NLM     Status:  MEDLINE    
Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy.
M D Hill; P A Barber; J Takahashi; A M Demchuk; T E Feasby; A M Buchan
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  162     ISSN:  0820-3946     ISO Abbreviation:  CMAJ     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-30     Completed Date:  2000-05-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1281-4     Citation Subset:  AIM; IM    
Department of Clinical Neurosciences, University of Calgary, Alta.
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MeSH Terms
Anaphylaxis / chemically induced*,  diagnosis
Angioedema / chemically induced*,  diagnosis
Cerebral Infarction / drug therapy*
Diagnosis, Differential
Drug Hypersensitivity / diagnosis*
Infusions, Intravenous
Thrombolytic Therapy*
Tissue Plasminogen Activator / administration & dosage,  adverse effects*
Reg. No./Substance:
EC Plasminogen Activator
Comment In:
CMAJ. 2000 Aug 22;163(4):387-9   [PMID:  10976251 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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