| Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke. | |
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MedLine Citation:
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PMID: 10813008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Among 105 patients given recombinant tissue plasminogen activator (rt-PA, alteplase) intravenously for acute stroke, 2 (1.9%) had lingual angioedema, which progressed to a fatal anaphylactoid reaction in 1. The authors review the 2 cases and possible mechanisms responsible. They warn that patients who are taking an angiotensin-converting-enzyme inhibitor may be at increased risk for angioedema with concomitant alteplase therapy. |
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Authors:
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M D Hill; P A Barber; J Takahashi; A M Demchuk; T E Feasby; A M Buchan |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 162 ISSN: 0820-3946 ISO Abbreviation: CMAJ Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-05-30 Completed Date: 2000-05-30 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: CANADA |
Other Details:
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Languages: eng Pagination: 1281-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Neurosciences, University of Calgary, Alta. michael.hill@crha-health.ab.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anaphylaxis / chemically induced*, diagnosis Angioedema / chemically induced*, diagnosis Cerebral Infarction / drug therapy* Diagnosis, Differential Drug Hypersensitivity / diagnosis* Female Humans Infusions, Intravenous Thrombolytic Therapy* Tissue Plasminogen Activator / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.68/Tissue Plasminogen Activator |
| Comments/Corrections | |
Comment In:
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CMAJ. 2000 Aug 22;163(4):387-9
[PMID:
10976251
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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