Document Detail

Anaphylactoid and anaphylactic reactions. Hazards of beta-blockers.
MedLine Citation:
PMID:  7669259     Owner:  NLM     Status:  MEDLINE    
Studies have demonstrated greater hazards associated with anaphylaxis in patients receiving beta-blockers. Serious anaphylaxis is more frequent. Evidence suggests this occurs via modulation of adenylate cyclase, which can influence release of anaphylactogenic mediators. Treatment of anaphylaxis in patients exposed to beta-blockers is complicated because therapeutic administration of epinephrine (adrenaline) may be ineffective or promote undesired alpha-adrenergic and vagotonic effects. Risk reduction efforts should be considered for patients receiving beta-blockers who are prone to experience anaphylaxis.
D M Lang
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Drug safety     Volume:  12     ISSN:  0114-5916     ISO Abbreviation:  Drug Saf     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-10-19     Completed Date:  1995-10-19     Revised Date:  2014-11-17    
Medline Journal Info:
Nlm Unique ID:  9002928     Medline TA:  Drug Saf     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  299-304     Citation Subset:  IM    
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects*,  pharmacokinetics
Anaphylaxis / chemically induced*
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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