| Anaphylactic shock caused by exposure to sea anemones. | |
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MedLine Citation:
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PMID: 17075255 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Since the first report of a dog that developed severe systemic symptoms in response to a second injection of sea anemone toxin by Richet and Portier in 1902, no clear human cases of anaphylaxis related to exposure to sea anemones has been reported in the literature. METHODS: A 24-year-old man with an episode of local urticaria on his first contact with a sea anemone (Stichodactyla haddoni), developed dyspnea, severe urticaria and hypotension on exposure to water containing the dead bodies of the organism. To study whether this reaction was mediated by antigen-specific IgE, we performed a histamine release test with blood, Western blotting with serum and lymphocyte proliferating test with peripheral blood mononuclear cells of the patient, for the homogenate of sea anemones. RESULTS: The homogenate of sea anemones induced histamine release from the blood of the patient, but it also induced histamine release from the blood of control subjects. Moreover, it also caused hemolysis of blood of all donors. However, Western-blotting demonstrated the presence of an 86 kd protein-specific IgE in the serum of the patient. CONCLUSIONS: Protein antigen(s) in sea anemones may cause anaphylactic shock under the influence of the cytolytic effects and/or lymphocyte-stimulating activity elicited by the toxin of sea anemones. |
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Authors:
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Keiko Nagata; Michihiro Hide; Toshihiko Tanaka; Kaori Ishii; Masao Izawa; Takeshi Sairenji; Katsuyuki Tomita; Eiji Shimizu |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Allergology international : official journal of the Japanese Society of Allergology Volume: 55 ISSN: 1323-8930 ISO Abbreviation: Allergol Int Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2006-11-22 Revised Date: 2008-03-06 |
Medline Journal Info:
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Nlm Unique ID: 9616296 Medline TA: Allergol Int Country: Australia |
Other Details:
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Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
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Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori, Japan. nanamon@theia.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anaphylaxis / diagnosis, immunology* Animals Humans Immunoglobulin E / physiology Male Sea Anemones / immunology* |
| Chemical | |
Reg. No./Substance:
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37341-29-0/Immunoglobulin E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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