Document Detail

Anaphylactic reactions during immunotherapy.
MedLine Citation:
PMID:  17493504     Owner:  NLM     Status:  MEDLINE    
Subcutaneous immunotherapy (IT) with aeroallergen extracts is venerable treatment modality. The major risk associated with IT with commercial aeroallergen extracts is the uncommon occurrence of severe near-fatal or fatal anaphylaxis after injections. The objectives of this article are to review the reported incidences of severe anaphylaxis (near-fatal reactions and fatal reactions), define factors contributing to these events, and identify preventive measures that are likely to reduce or eliminate future fatal and near-fatal anaphylactic events. As with any treatment, anticipated benefits attributed to IT must be weighed against its potential risks.
Maziar Rezvani; David I Bernstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology and allergy clinics of North America     Volume:  27     ISSN:  0889-8561     ISO Abbreviation:  Immunol Allergy Clin North Am     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8805635     Medline TA:  Immunol Allergy Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-307, viii     Citation Subset:  IM    
Division of Allergy/Immunology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0563, USA.
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MeSH Terms
Allergens / adverse effects,  therapeutic use
Anaphylaxis / epidemiology*,  etiology*,  prevention & control*
Desensitization, Immunologic / adverse effects*
Hypersensitivity / therapy
Injections, Subcutaneous
Risk Factors
Reg. No./Substance:

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