Document Detail

Anaphase progression and furrow establishment in nocodazole-arrested PtK1 cells.
MedLine Citation:
PMID:  7273957     Owner:  NLM     Status:  MEDLINE    
The relationship between progression through anaphase and furrow establishment was investigated in PtK1 cells using the anti-mitotic agent Nocodazole to arrest cells at different points in anaphase. The capacity of cells to furrow was compared to the kinetochore-kinetochore separation attained at the time of arrest. For the stages of anaphase examined, furrowing capacity increased directly with kinetochore-kinetochore separation until complete furrows were formed after kinetochore-kinetochore separations of 14 micron or more were reached. Furrow establishment thus occurs during a definite interval during anaphase in PtK1 cells. Results from electron microscopy of both Nocodazole-treated and control cells suggest that a population of astral microtubules may be important for furrow establishment.
J M Mullins; J A Snyder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chromosoma     Volume:  83     ISSN:  0009-5915     ISO Abbreviation:  Chromosoma     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985138R     Medline TA:  Chromosoma     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  493-505     Citation Subset:  IM    
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MeSH Terms
Anaphase / drug effects*
Benzimidazoles / pharmacology*
Carbamates / pharmacology*
Cell Line
Chromosomes / ultrastructure
Microscopy, Electron
Grant Support
Reg. No./Substance:
0/Benzimidazoles; 0/Carbamates; 31430-18-9/Nocodazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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