| Analyzing the neocortical fine-structure. | |
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MedLine Citation:
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PMID: 12946467 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytoarchitectonic fields of the human neocortex are defined by characteristic variations in the composition of a general six-layer structure. It is commonly accepted that these fields correspond to functionally homogeneous entities. Diligent techniques were developed to characterize cytoarchitectonic fields by staining sections of post-mortem brains and subsequent statistical evaluation. Fields were found to show a considerable interindividual variability in extent and relation to macroscopic anatomical landmarks. With upcoming new high-resolution magnetic resonance imaging (MRI) protocols, it appears worthwhile to examine the feasibility of characterizing the neocortical fine-structure from anatomical MRI scans, thus, defining neocortical fields by in vivo techniques. A fixated brain hemisphere was scanned at a resolution of approximately 0.3 mm. After correcting for intensity inhomogeneities in the dataset, the cortex boundaries (the white/grey matter and grey matter/background interfaces) were determined as a triangular mesh. Radial intensity profiles following the shortest path through the cortex were computed and characterized by a sparse set of features. A statistical similarity measure between features of different regions was defined, and served to define the extent of Brodmann's Areas 4, 17, 44 and 45 in this dataset. |
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Authors:
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F Kruggel; M K Brückner; Th Arendt; C J Wiggins; D Y von Cramon |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Validation Studies |
Journal Detail:
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Title: Medical image analysis Volume: 7 ISSN: 1361-8415 ISO Abbreviation: Med Image Anal Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-29 Completed Date: 2004-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9713490 Medline TA: Med Image Anal Country: England |
Other Details:
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Languages: eng Pagination: 251-64 Citation Subset: IM |
Affiliation:
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Max-Planck-Institute of Cognitive Neuroscience, Stephanstrasse 1, 04103 Leipzig, Germany. kruggel@cns.mpg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Algorithms* Cadaver Cerebral Cortex / anatomy & histology, cytology Feasibility Studies Female Frontal Lobe / anatomy & histology, cytology Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Imaging, Three-Dimensional / methods* Magnetic Resonance Imaging / methods* Motor Cortex / anatomy & histology, cytology Neocortex / anatomy & histology*, cytology Nerve Net / anatomy & histology, cytology Pattern Recognition, Automated Somatosensory Cortex / anatomy & histology, cytology Visual Cortex / anatomy & histology, cytology |
| Comments/Corrections | |
Erratum In:
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Med Image Anal. 2006 Aug;10(4):611 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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