Document Detail


Analytical versus clinical sensitivity and specificity in pregnancy testing.
MedLine Citation:
PMID:  3348324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A typical urine pregnancy test with the enzyme-linked immunoassay for human chorionic gonadotropin (Tandem Icon human chorionic gonadotropin) was performed as was a qualitative serum radioimmunoassay for human chorionic gonadotropin when the positive cutoff for the latter was set at 30 IU/L. There was 99.5% concordance between the two methods when performed on 871 simultaneous urine and serum specimens. Although the serum radioimmunoassay can detect levels of human chorionic gonadotropin as low as 10 IU/L, in this study the majority of patients with serum levels between 10 and 30 IU/L were not pregnant on clinical follow-up. Of nine patients with adequate clinical follow-up, a negative urine pregnancy test result, and a serum human chorionic gonadotropin level between 10 and 30 IU/L, only one proved to be pregnant. The Tandem Icon human chorionic gonadotropin urine test is sufficient for routine pregnancy testing and to rule out the need for immediate intervention in cases of ectopic pregnancy.
Authors:
K Emancipator; E M Cadoff; M D Burke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  158     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-20     Completed Date:  1988-04-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  613-6     Citation Subset:  AIM; IM; J    
Affiliation:
Department of Pathology, State University of New York, Stony Brook.
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MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / blood,  urine
Enzyme-Linked Immunosorbent Assay
False Positive Reactions
Female
Humans
Pregnancy
Pregnancy Tests*
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 1989 Sep;161(3):835-6   [PMID:  2675612 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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