Document Detail

Analytical method comparison based upon statistical power calculations.
MedLine Citation:
PMID:  1608889     Owner:  NLM     Status:  MEDLINE    
Testing for the equivalence of results generated by different analytical methodology is a common practice in the pharmaceutical sciences. Methodology changes are implemented for both scientific and economic reasons during a scientific study. Thus, the need to demonstrate the appropriateness of considering data generated by distinct methods as part of a single information population arises. This paper describes a rapid and simple approach to the statistical design and interpretation of method comparison experiments. The approach presented is based upon a statistical power calculation technique, a knowledge of the variability associated with the methods to be compared and the criteria for equivalence (the limits within which differences become immeasurable or, for practical purposes, insignificant). Reference tables are included which show necessary sample sizes for comparison experiments for common combinations of these three variables.
D J Mazzo; M Connolly
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pharmaceutical research     Volume:  9     ISSN:  0724-8741     ISO Abbreviation:  Pharm. Res.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-07-22     Completed Date:  1992-07-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8406521     Medline TA:  Pharm Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  601-6     Citation Subset:  IM    
Department of Analytical and Physical Chemistry, Rhône-Poulenc Rorer Central Research, Fort Washington, Pennsylvania 19034.
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MeSH Terms
Chemistry Techniques, Analytical / methods*
Data Interpretation, Statistical*
Reproducibility of Results

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