Document Detail

Analytical measurement and clinical relevance of vitamin D(3) C3-epimer.
MedLine Citation:
PMID:  23153571     Owner:  NLM     Status:  MEDLINE    
With an ever-increasing clinical interest in vitamin D insufficiency, numerous automated immunoassays, protein binding assays, and in-house LC-MS/MS methods are being developed for the quantification of 25-hydroxyvitamin D(3) (25(OH)D(3)). Recently, LC-MS/MS methods have identified an epimeric form of 25(OH)D(3) that has been shown to contribute significantly to 25(OH)D(3) concentration, particularly in infant populations. This review describes the metabolic pathway and physiological functions of 3-epi-vitamin D, compares the capability of various 25(OH)D(3) methods to detect the epimer, and highlights recent publications quantifying 3-epi-25(OH)D(3) in infant, pediatric, and adult populations. In total, this review summarizes the information necessary for clinicians and laboratorians to decide whether or not to report/consider the C3-epimer in the analysis and clinical assessment of vitamin D status.
Dana Bailey; Kika Veljkovic; Mehrdad Yazdanpanah; Khosrow Adeli
Publication Detail:
Type:  Journal Article; Review     Date:  2012-11-12
Journal Detail:
Title:  Clinical biochemistry     Volume:  46     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-07-03     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Age Factors
Calcifediol / analogs & derivatives*,  analysis*,  metabolism
Calcitriol / analysis,  metabolism
Calcium / metabolism
Chromatography, Liquid / methods
Clinical Chemistry Tests / methods
Dietary Supplements / analysis*
Limit of Detection
Mass Spectrometry / methods
Reproducibility of Results
Steroid Hydroxylases / metabolism
Vitamin D Deficiency / diagnosis
Reg. No./Substance:
EC 1.14.-/Steroid Hydroxylases; EC D 24-hydroxylase; FXC9231JVH/Calcitriol; P6YZ13C99Q/Calcifediol; SY7Q814VUP/Calcium

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