Document Detail


Analytical evaluation of the new Abbott Architect 25-OH vitamin D assay.
MedLine Citation:
PMID:  22321565     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Validation of the Architect 25-OH vitamin D assay. DESIGN AND METHODS: Determination of repeatability, reproducibility, accuracy profile and 25(OH)-vitamin D2 recovery on native samples. Comparison with DiaSorin Liaison and RIA. RESULTS AND CONCLUSION: Coefficients of variation: <6% (13.6ng/mL) and 2.2% (78.1ng/mL). Functional sensitivity: 5ng/mL. Accuracy profile shows that the method is validated between 13.6 and 78.1ng/mL. Recovery of 25(OH)D2: 75,8%( 95% CI: 61.9-89.7%). Good correlation with DiaSorin RIA and Liaison <50ng/mL; above this threshold a systematic positive bias was observed.
Authors:
Etienne Cavalier; Agnes Carlisi; Anne-Catherine Bekaert; Olivier Rousselle; Jean-Paul Chapelle; Jean-Claude Souberbielle
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-1
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Department of Clinical Chemistry, University of Liege, CHU Sart-Tilman, Liège, Belgium.
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