Document Detail

Analytical approximations of sensitivities of steady state predictions to errors in parameter estimation: II. Michaelis-Menten kinetics.
MedLine Citation:
PMID:  6520746     Owner:  NLM     Status:  MEDLINE    
Linear sensitivity theory is used to estimate the reliability of predictions of the minimum and maximum concentrations at steady state in the Michaelis-Menten model with i.v. bolus. The dependence of the relative errors in the predictions on the errors in the pharmacokinetic parameters is derived in an analytical form. It is shown that the quality of the predictions is not equally sensitive to all errors in parameters, and that the sensitivity factors vary with the degree of saturation of the system. An example of application for a drug, such as phenytoin, is discussed. It is suggested that sensitivity analysis may be useful in design of pharmacokinetic experiments aimed at the control of steady state levels for drugs with Michaelis-Menten kinetics.
I Gonda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacokinetics and biopharmaceutics     Volume:  12     ISSN:  0090-466X     ISO Abbreviation:  J Pharmacokinet Biopharm     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-03-14     Completed Date:  1985-03-14     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0357115     Medline TA:  J Pharmacokinet Biopharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-34     Citation Subset:  IM    
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MeSH Terms
Models, Biological
Pharmaceutical Preparations / metabolism
Phenytoin / metabolism
Reg. No./Substance:
0/Pharmaceutical Preparations; 57-41-0/Phenytoin

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