Document Detail

Analytical approximations of sensitivities of steady state predictions to errors in parameter estimation: II. Michaelis-Menten kinetics.
MedLine Citation:
PMID:  6520746     Owner:  NLM     Status:  MEDLINE    
Linear sensitivity theory is used to estimate the reliability of predictions of the minimum and maximum concentrations at steady state in the Michaelis-Menten model with i.v. bolus. The dependence of the relative errors in the predictions on the errors in the pharmacokinetic parameters is derived in an analytical form. It is shown that the quality of the predictions is not equally sensitive to all errors in parameters, and that the sensitivity factors vary with the degree of saturation of the system. An example of application for a drug, such as phenytoin, is discussed. It is suggested that sensitivity analysis may be useful in design of pharmacokinetic experiments aimed at the control of steady state levels for drugs with Michaelis-Menten kinetics.
I Gonda
Related Documents :
12848776 - Physiologically based modelling of inhibition of metabolism and assessment of the relat...
17164696 - Application of routine monitoring data for determination of the population pharmacokine...
1332596 - Investigation of the early killing of staphylococcus aureus by daptomycin by using an i...
12021626 - Nonmem and npem2 population modeling: a comparison using tobramycin data in neonates.
25105606 - Reheating constraints to inflationary models.
20192796 - Advances in analysis of longitudinal data.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacokinetics and biopharmaceutics     Volume:  12     ISSN:  0090-466X     ISO Abbreviation:  J Pharmacokinet Biopharm     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-03-14     Completed Date:  1985-03-14     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0357115     Medline TA:  J Pharmacokinet Biopharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  525-34     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Models, Biological
Pharmaceutical Preparations / metabolism
Phenytoin / metabolism
Reg. No./Substance:
0/Pharmaceutical Preparations; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Induction of quinidine metabolism and plasma protein binding by phenobarbital in dogs.
Next Document:  Extended least squares nonlinear regression: a possible solution to the "choice of weights" problem ...