Document Detail

Analytical applications of electrodes modified by gold nanoparticles: dopamine detection.
MedLine Citation:
PMID:  19437983     Owner:  NLM     Status:  MEDLINE    
Dopamine oxidation was studied on modified gold (nano-Au) electrodes obtained by Layer-by-Layer deposition of gold nanoparticles and polyacrylic acid. A gradual loss of electrochemical activity for the dopamine oxidation reaction is observed at pH 7. Simultaneous SPR spectroscopy and cyclic voltammetry indicate the formation of an adsorbed layer on the electrode surface at this pH value. Investigations, performed through electrochemical and SPR measurements at pH 4, give evidence for a reversible process. At this pH value both dopamine oxidation and reduction current peaks show linear dependence on the dopamine concentration and may be used for analytical applications. The use of the nano-Au electrode allows resolving the peaks corresponding to ascorbic acid and to dopamine oxidation by 240 mV thus providing a high selectively for dopamine detection in the presence of ascorbic acid. The detection limit of this electrode for dopamine is below 4 microM in the presence of 1 mM ascorbic acid. The sensitivity normalized to the macroscopic electrode surface is about 10 mA cm(-2) mM(-1) at sweep rate of 10 V/s.
Fredy Kurniawan; Vessela Tsakova; Vladimir M Mirsky
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  9     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-14     Completed Date:  2009-06-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2407-12     Citation Subset:  IM    
Institute of Analytical Chemistry, Chemo and Biosensors, University of Regensburg, D-93040 Regensburg, Germany.
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MeSH Terms
Acrylic Resins / chemistry
Ascorbic Acid / analysis
Chemistry Techniques, Analytical / methods*
Dopamine / analysis*
Electrochemistry / methods
Gold / chemistry*
Hydrogen-Ion Concentration
Metal Nanoparticles / chemistry*
Sensitivity and Specificity
Reg. No./Substance:
0/Acrylic Resins; 50-81-7/Ascorbic Acid; 7440-57-5/Gold; 9003-01-4/carbopol 940

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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