| Analytic reviews: propofol infusion syndrome in the ICU. | |
| | |
MedLine Citation:
|
PMID: 21464061 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Propofol is an alkylphenol derivative named 2, 6, diisopropylphenol and is a potent intravenous short-acting hypnotic agent. It is commonly used as sedation, as well as an anesthetic agent in both pediatric and adult patient populations. There have been numerous case reports describing a constellation of findings including metabolic derangements and organ system failures known collectively as propofol infusion syndrome (PRIS). Although there is a high mortality associated with PRIS, the precise mechanism of action has yet to be determined. The best preventive measure for this syndrome is awareness and avoidance of clinical scenarios associated with development of PRIS. There is no established treatment for PRIS; care is primarily supportive in nature and may include the full array of advanced cardiopulmonary support, including extracorporeal membrane oxygenation (ECMO). This article reviews the reported cases of PRIS and describes the current understanding of the underlying pathophysiology and treatment options. |
| | |
Authors:
|
Daniel A Diedrich; Daniel R Brown |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of intensive care medicine Volume: 26 ISSN: 1525-1489 ISO Abbreviation: J Intensive Care Med Publication Date: 2011 Mar-Apr |
Date Detail:
|
Created Date: 2011-04-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8610344 Medline TA: J Intensive Care Med Country: United States |
Other Details:
|
Languages: eng Pagination: 59-72 Citation Subset: IM |
Affiliation:
|
Division of Critical Care, Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Mortality Associated With Atrial Fibrillation in Patients With Myocardial Infarction: A Systematic R...
Next Document: Interleukin-6 in Surgery, Trauma, and Critical Care Part II: Clinical Implications.