Document Detail

Analytic review: management of life-threatening asthma in adults.
MedLine Citation:
PMID:  20085924     Owner:  NLM     Status:  In-Process    
Asthma remains a troubling health problem despite the availability of effective treatment. A small but significant number of asthmatics experience life-threatening attacks culminating in intensive care unit admission. Standard treatment includes high dose systemic corticosteroids and inhaled bronchodilators. Patients with especially severe attacks may develop respiratory failure and need endotracheal intubation and mechanical ventilation. Severe airway obstruction may lead to dynamic hyperinflation and the possibility of hemodynamic collapse and barotrauma. Fortunately, most intubated asthmatics survive if physicians adhere to key management principles intended to avoid or minimize hyperinflation. The purpose of this review is to discuss the pathogenesis of life-threatening asthma and to provide practical guidance to promote rationale, safe, and effective management.
Praveen Mannam; Mark D Siegel
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  25     ISSN:  1525-1489     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2010 Jan-Feb
Date Detail:
Created Date:  2010-01-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-15     Citation Subset:  IM    
Pulmonary and Critical Care Section, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
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