Document Detail


Analytic review: interleukin-6 in surgery, trauma, and critical care: part I: basic science.
MedLine Citation:
PMID:  21262749     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit.
Authors:
Randeep S Jawa; Sergio Anillo; Kristin Huntoon; Heinz Baumann; Mahmoud Kulaylat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  26     ISSN:  1525-1489     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2011 Jan-Feb
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3-12     Citation Subset:  IM    
Affiliation:
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. rjawa@unmc.edu.
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