| Analytic review: interleukin-6 in surgery, trauma, and critical care: part I: basic science. | |
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MedLine Citation:
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PMID: 21262749 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A variety of cytokines play a role in the response to an inflammatory stimulus. The interleukin-6 (IL-6)-type cytokines are released in response to tissue injury or an inflammatory stimulus. They act locally and systemically to generate a variety of physiologic responses, principal among them is the acute phase response. The IL-6 type cytokines demonstrate pleiotropy and redundancy of actions. This is made possible by the distinctive characteristics of the IL-6 receptor complex, which contains an ubiquitous subunit that is shared by most IL-6-type cytokines, as well as a cytokine-specific subunit. |
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Authors:
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Randeep S Jawa; Sergio Anillo; Kristin Huntoon; Heinz Baumann; Mahmoud Kulaylat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of intensive care medicine Volume: 26 ISSN: 1525-1489 ISO Abbreviation: J Intensive Care Med Publication Date: 2011 Jan-Feb |
Date Detail:
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Created Date: 2011-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8610344 Medline TA: J Intensive Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 3-12 Citation Subset: IM |
Affiliation:
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Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA. rjawa@unmc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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