Document Detail


Analytic epidemiology and periodontal diseases.
MedLine Citation:
PMID:  22133370     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The validity of epidemiological and clinical observations is paramount, not only for scientific advancement but also in evidence-based practice. Concern regarding validity with respect to the design and conduct of analytic epidemiological studies is often under-appreciated, partly as a consequence of our focus on randomized experimental designs as the highest standard of 'proof' in clinical science. We review the design, conduct and interpretation of rigorous analytic epidemiological study designs, with specific reference to periodontology. We give special emphasis to intrinsic validity and the use of focused aims to re-frame the perspective on the strength of evidence in reviews of the literature. Specifically, we draw on the periodontal research literature to provide an overview of the appropriate design and conduct of cohort studies, including randomized designs, case-control and cross-sectional studies. The concepts of selection bias, information bias and confounding are explored for each study design, both in general terms and with respect to a critical review of the literature on the epidemiology of periodontal diseases.
Authors:
Brenda Heaton; Thomas Dietrich
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Periodontology 2000     Volume:  58     ISSN:  1600-0757     ISO Abbreviation:  Periodontol. 2000     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2011-12-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9313276     Medline TA:  Periodontol 2000     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  112-20     Citation Subset:  D    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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