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Analytic considerations for measuring environmental chemicals in breast milk.
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MedLine Citation:
PMID:  12055062     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of environmental chemicals in human breast milk is of general concern because of the potential health consequence of these chemicals to the breast-fed infant and the mother. In addition to the mother's exposure, several features determine the presence of environmental chemicals in breast milk and their ability to be determined analytically. These include maternal factors and properties of the environmental chemical--both physical and chemical--such as its lipid solubility, degree of ionization, and molecular weight. Environmental chemicals with high lipid solubility are likely to be found in breast milk; they include polyhalogenated compounds such as polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, organochlorine insecticides, and polybrominated diphenylethers. These fat-soluble chemicals are incorporated into the milk as it is synthesized, and they must be measured in accordance with the fat content of the milk to allow for meaningful comparisons within an individual and among populations. Although the analytic approach selected to measure the environmental chemical is predominantly determined by the characteristics of the chemical, the concentration of the chemical in the milk sample and the existence of structurally similar chemicals (e.g., congeners) must be considered as well. In general, the analytic approach for measuring environmental chemicals in breast milk is similar to the approach for measuring the same chemicals in other matrices, except special considerations must be given for the relatively high fat content of milk. The continued efforts of environmental scientists to measure environmental chemicals in breast milk is important for defining the true contribution of these chemicals to public health, especially to the health of the newborn. Work is needed for identifying and quantifying additional environmental chemicals in breast milk from the general population and for developing analytic methods that have increased sensitivity and the ability to speciate various chemicals.
Authors:
Larry L Needham; Richard Y Wang
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Environmental health perspectives     Volume:  110     ISSN:  0091-6765     ISO Abbreviation:  Environ. Health Perspect.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-10     Completed Date:  2002-07-23     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0330411     Medline TA:  Environ Health Perspect     Country:  United States    
Other Details:
Languages:  eng     Pagination:  A317-24     Citation Subset:  IM    
Affiliation:
Toxicology Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemistry Techniques, Analytical / methods
Environmental Pollutants / analysis*
Fats
Female
Humans
Milk, Human / chemistry*
Public Health
Reproducibility of Results
Sensitivity and Specificity
Solubility
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 0/Fats
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Environ Health Perspect
ISSN: 0091-6765
Article Information
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Print publication date: Month: 6 Year: 2002
Volume: 110 Issue: 6
First Page: A317 Last Page: A324
ID: 1240885
PubMed Id: 12055062
Publisher Item Identifier: sc271_5_1835

Analytic considerations for measuring environmental chemicals in breast milk.
Larry L Needham
Richard Y Wang
Toxicology Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.


Article Categories:
  • Research Article


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