Document Detail


Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder.
MedLine Citation:
PMID:  15588756     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anticipation phenomenon, described as either an increase in disease severity, a decrease in age at onset, or both, in successive generations, has been suggested as a possibility of genetic transmission for bipolar affective disorder. We report here investigation of the stability of intergenerational transmission of a variable number tandem repeat (VNTR) polymorphism, found in the Huntingtin interacting protein-1 related gene (HIP12/HIP1R) that is mapped to the chromosome 12q24.31 region, in nine pedigrees showing decreased age at onset in successive generations. We did not observe any allelic instability but we report a deletion that includes this VNTR polymorphism. Allelic and genotypic association studies should be undertaken to verify the involvement of HIP12/HIP1R in bipolar disorder.
Authors:
Nadine Provençal; Eric Shink; Mario Harvey; Monique Tremblay; Nicholas Barden
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  28     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-03-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1299-303     Citation Subset:  IM    
Affiliation:
Neuroscience, CHUL Research Center and Laval University, CHUQ Pavillon CHUL, 2705 Boulevard Laurier, Ste-Foy, Québec, Canada G1V 4G2.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Aged, 80 and over
Bipolar Disorder / genetics*
Chromosome Mapping / methods
Chromosomes, Human, Pair 12
DNA-Binding Proteins / genetics*
Female
Genotype
Humans
Introns
Male
Middle Aged
Minisatellite Repeats / genetics*
Pedigree
Polymorphism, Genetic*
RNA, Messenger / biosynthesis
Reverse Transcriptase Polymerase Chain Reaction / methods
Vesicular Transport Proteins
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/HIP1R protein, human; 0/RNA, Messenger; 0/Vesicular Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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