Document Detail

Analysis of treatment results in 36 children with retinoblastoma treated by scleral plaque irradiation.
MedLine Citation:
PMID:  2745209     Owner:  NLM     Status:  MEDLINE    
This is a retrospective analysis of treatment results in 36 patients with retinoblastoma treated by the Radiation Oncology Department of Hahnemann University Hospital and the Division of Oncology of Wills Eye Hospital between January 1975 and December 1986. There were 14 females and 22 males; ages ranged from 2 months to 4 1/2 years of age at presentation. Leukocoria was the most common clinical sign of presentation. These patients were treated with external beam radiation therapy in combination with scleral plaque irradiation in 20 patients and with scleral plaque alone in 16 patients. Cobalt-60, Iodine-125, Iridium-192, and Ruthenium-106, scleral plaques were used. The dose delivered to the mid plane of the globe was 40 Gy and the scleral dose adjacent to the plaque was in the range of 180-200 Gy. The treatment was successful in 30 of 36 patients. Complications of radiation therapy were minimal in patients treated by scleral plaque alone. The advantages of this treatment modality are discussed.
B E Amendola; A M Markoe; J J Augsburger; U L Karlsson; M Giblin; J A Shields; L W Brady; R Woodleigh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  17     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-11     Completed Date:  1989-08-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-70     Citation Subset:  IM    
Department of Radiation Oncology and Nuclear Medicine, Hahnemann University, Philadelphia, PA 19102.
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MeSH Terms
Bone Neoplasms / secondary
Child, Preschool
Cobalt Radioisotopes / therapeutic use
Eye Neoplasms / pathology,  radiotherapy*
Iodine Radioisotopes / therapeutic use
Iridium Radioisotopes / therapeutic use
Neoplasm Staging
Neoplasms, Multiple Primary / pathology,  radiotherapy
Orbital Neoplasms / secondary
Radiotherapy Dosage
Remission Induction
Retinoblastoma / pathology,  radiotherapy*,  secondary
Retrospective Studies
Ruthenium Radioisotopes / therapeutic use
Visual Acuity
Reg. No./Substance:
0/Cobalt Radioisotopes; 0/Iodine Radioisotopes; 0/Iridium Radioisotopes; 0/Ruthenium Radioisotopes

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