Document Detail


Analysis of the transforming growth factor beta1 gene -509 C/T polymorphism in patients with advanced-stage endometriosis.
MedLine Citation:
PMID:  19249027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether the transforming growth factor beta (TGF-beta) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis. DESIGN: Case-control study. SETTING: University department of obstetrics and gynecology. PATIENT(S): Women with advanced-stage endometriosis (n = 485) and without endometriosis (n = 352). INTERVENTION(S): Genotyping by real-time polymerase chain reaction using a Taqman assay. MAIN OUTCOME MEASURE(S): Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-beta1 gene. RESULT(S): The genotype distribution of the TGF-beta1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group. CONCLUSION(S): These results suggest that the TGF-beta1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis.
Authors:
Jin Ju Kim; Young Min Choi; Seon Ha Choung; Sang Ho Yoon; Kyu Sup Lee; Seung Yup Ku; Jung Gu Kim; Shin Yong Moon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-26
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-05-25     Revised Date:  2010-09-03    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2121-4     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
DNA Mutational Analysis
Disease Progression
Endometriosis / genetics*
Female
Gene Frequency
Genotype
Humans
Middle Aged
Ovarian Diseases / genetics*
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic / genetics
Transforming Growth Factor beta1 / genetics*
Chemical
Reg. No./Substance:
0/Transforming Growth Factor beta1
Comments/Corrections
Comment In:
Fertil Steril. 2010 Sep;94(4):e63; author reply e64   [PMID:  20663498 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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