Document Detail

Analysis of temperature-sensitive recB and recC mutations.
MedLine Citation:
PMID:  1103836     Owner:  NLM     Status:  MEDLINE    
The in vivo pleiotropic effects associated with the temperature-sensitive recB270 and recC271 mutations have been correlated with the in vitro behavior of the recBC nucleases coded for by these alleles. The ATP-dependent breakdown of double-stranded DNA is essential for cell viability, radiation repair, and genetic recombination. Temperature sensitivity can be suppressed in vitro and in vivo.
S R Kushner
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Basic life sciences     Volume:  5A     ISSN:  0090-5542     ISO Abbreviation:  Basic Life Sci.     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-02     Completed Date:  1976-02-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0360077     Medline TA:  Basic Life Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphate / pharmacology
Cell Survival
DNA, Bacterial / metabolism*
Deoxyribonucleases / metabolism
Endonucleases / metabolism
Escherichia coli / drug effects,  metabolism*,  radiation effects
Exonucleases / metabolism
Mitomycins / pharmacology
Radiation Effects
Recombination, Genetic*
Ultraviolet Rays
Reg. No./Substance:
0/DNA, Bacterial; 0/Mitomycins; 56-65-5/Adenosine Triphosphate; EC 3.1.-/Deoxyribonucleases; EC 3.1.-/Endonucleases; EC 3.1.-/Exonucleases

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