Document Detail

Analysis strategies for adaptive designs with multiple endpoints.
MedLine Citation:
PMID:  18027225     Owner:  NLM     Status:  MEDLINE    
The problem of analysis strategies for adaptive designs with multiple endpoints is considered. We first provide a review of the commonly used methods for addressing the issue of multiplicity in classical designs, followed by the gatekeeper procedure and the fractal gatekeeper procedure. The latter will be applied to address the issue of multiplicity in adaptive trials with multiple endpoints based on the invariance property of the test statistic employed. Practical examples are presented to illustrate the proposed fractal gatekeeper method when analyzing data obtained from an adaptive trial with multiple endpoints.
Mark Chang; Shein-Chung Chow
Related Documents :
18999175 - Clinical trials in silico: rigorous assessment of treatment effect using electronic hea...
20433715 - Multicenter data acquisition made easy.
17591655 - Pharmacological models in healthy volunteers: their use in the clinical development of ...
2199875 - A guide to interpreting contraceptive efficacy studies.
9684375 - Dynamics of a feline retrovirus (felv) in host populations with variable spatial struct...
17827045 - Ontogenetic scaling of fish metabolism in the mouse-to-elephant mass magnitude range.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of biopharmaceutical statistics     Volume:  17     ISSN:  1054-3406     ISO Abbreviation:  J Biopharm Stat     Publication Date:  2007  
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-01-17     Revised Date:  2008-03-31    
Medline Journal Info:
Nlm Unique ID:  9200436     Medline TA:  J Biopharm Stat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1189-200     Citation Subset:  IM    
Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Clinical Trials as Topic / methods,  statistics & numerical data*
Endpoint Determination / statistics & numerical data*
Research Design / statistics & numerical data*
Erratum In:
J Biopharm Stat. 2008;18(2):402

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Seamless Phase II/III combination study through response adaptive randomization.
Next Document:  Statistical considerations for testing multiple endpoints in group sequential or adaptive clinical t...