Document Detail


Analysis of stimulus-related activity in rat auditory cortex using complex spectral coefficients.
MedLine Citation:
PMID:  23657279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The neural mechanisms of sensory responses recorded from the scalp or cortical surface remain controversial. Evoked vs. induced response components (i.e., changes in mean vs. variance) are associated with bottom-up vs. top-down processing, but trial-by-trial response variability can confound this interpretation. Phase reset of ongoing oscillations has also been postulated to contribute to sensory responses. In this article, we present evidence that responses under passive listening conditions are dominated by variable evoked response components. We measured the mean, variance, and phase of complex time-frequency coefficients of epidurally recorded responses to acoustic stimuli in rats. During the stimulus, changes in mean, variance, and phase tended to co-occur. After the stimulus, there was a small, low-frequency offset response in the mean and modest, prolonged desynchronization in the alpha band. Simulations showed that trial-by-trial variability in the mean can account for most of the variance and phase changes observed during the stimulus. This variability was state dependent, with smallest variability during periods of greatest arousal. Our data suggest that cortical responses to auditory stimuli reflect variable inputs to the cortical network. These analyses suggest that caution should be exercised when interpreting variance and phase changes in terms of top-down cortical processing.
Authors:
Bryan M Krause; Matthew I Banks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-05-08
Journal Detail:
Title:  Journal of neurophysiology     Volume:  110     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-08-02     Completed Date:  2014-02-18     Revised Date:  2014-08-03    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  621-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Auditory Cortex / physiology*
Data Interpretation, Statistical
Evoked Potentials, Auditory*
Female
Rats
Grant Support
ID/Acronym/Agency:
DC006013/DC/NIDCD NIH HHS; R01 DC006013/DC/NIDCD NIH HHS; T32-GM007507/GM/NIGMS NIH HHS
Comments/Corrections

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