Document Detail

Analysis of the sputum and inflammatory alterations of the airways in patients with common variable immunodeficiency and bronchiectasis.
MedLine Citation:
PMID:  20037702     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Common variable immunodeficiency is characterized by defective antibody production and recurrent pulmonary infections. Intravenous immunoglobulin is the treatment of choice, but the effects of Intravenous immunoglobulin on pulmonary defense mechanisms are poorly understood.
OBJECTIVE: The aim of this study was to verify the impact of intravenous immunoglobulin on the physical properties of the sputum and on inflammatory alterations in the airways of patients with Common variable immunodeficiency associated with bronchiectasis.
METHOD: The present study analyzed sputum physical properties, exhaled NO, inflammatory cells in the sputum, and IG titers in 7 patients with Common variable immunodeficiency and bronchiectasis with secretion, immediately before and 15 days after Intravenous immunoglobulin. A group of 6 patients with Common variable immunodeficiency and bronchiectasis but no sputum was also studied for comparison of the basal IgG level and blood count. The 13 patients were young (age=36+/-17 years) and comprised predominantly of females (n=11).
RESULTS: Patients with secretion presented significantly decreased IgG and IgM levels. Intravenous immunoglobulin was associated with a significant decrease in exhaled NO (54.7 vs. 40.1 ppb, p<0.05), sputum inflammatory cell counts (28.7 vs. 14.6 cells/mm(3), p<0.05), and a significant increase in respiratory mucus transportability by cough (42.5 vs. 65.0 mm, p < 0.05).
CONCLUSION: We concluded that immunoglobulin administration in Common variable immunodeficiency patients results in significant improvement in indexes of inflammation of the airways with improvement in the transportability of the respiratory mucus by cough.
Andrea Cristina Pereira; Cristina M Kokron; Beatriz Mangueira Saraiva Romagnolo; Claudia Simeire Albertini Yagi; Paulo Hilário Nascimento Saldiva; Geraldo Lorenzi Filho; Elnara Marcia Negri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  64     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-28     Completed Date:  2010-07-23     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  1155-60     Citation Subset:  IM    
Pathology Department, Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil.
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MeSH Terms
Bronchiectasis* / drug therapy,  immunology,  physiopathology
Cell Count
Common Variable Immunodeficiency* / drug therapy,  immunology,  physiopathology
Cough / immunology,  physiopathology
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Immunoglobulins, Intravenous / therapeutic use*
Mucociliary Clearance / physiology*
Mucus / physiology
Nitric Oxide / analysis
Respiratory Tract Infections* / drug therapy,  immunology,  physiopathology
Sputum* / cytology,  drug effects,  immunology
Statistics, Nonparametric
Time Factors
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 0/Immunoglobulins, Intravenous; 10102-43-9/Nitric Oxide

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