Document Detail

Analysis of sister-chromatid exchanges (SCEs) in familial and sporadic multiple sclerosis.
MedLine Citation:
PMID:  3702896     Owner:  NLM     Status:  MEDLINE    
The levels of sister-chromatid exchanges (SCEs) were calculated in 17 multiple sclerosis (MS) patients (14 familial and 3 sporadic cases) and 16 healthy controls matched for sex and age. The SCEs were significantly increased for MS patients (p = 0.0002), while there was no statistically significant difference between men and women and between younger and older subjects in both groups. Such factors as familial occurrence and severity of MS, smoking habits, and distribution of lymphocyte subpopulations were discussed. Although there was a significant difference between the MS patients taking medication and the patients taking none (p = 0.038), the latter were still significantly different from the controls (p = 0.035), supporting the fact that the disease itself increases SCEs. Our study, done with 2 doses of BrdU, also shows that the increased SCEs in MS patients are not due to a hypersensitivity to this substance known to be an inducer of SCEs. Thus we suggest that the increased SCEs found are probably disease-related.
M Senécal-Quevillon; P Duquette; C L Richer
Related Documents :
1247936 - Fluorescein angiography and retinal venous sheathing in multiple sclerosis.
17895416 - The relationship between hla-drb1 alleles and optic neuritis in irish patients and the ...
174916 - Olfaction in multiple sclerosis. with a note on the discrepancy between optic and olfac...
8610486 - Tests of autonomic dysfunction in patients with multiple sclerosis.
17610536 - Myocardial iron loading by magnetic resonance imaging t2* in good prognostic myelodyspl...
6754416 - The effect of budesonide in perennial rhinitis.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  161     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-06-20     Completed Date:  1986-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-74     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Age Factors
Cells, Cultured
Lymphocytes / cytology
Middle Aged
Multiple Sclerosis / genetics*,  physiopathology
Reference Values
Sex Factors
Sister Chromatid Exchange*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Altered CTP synthetase activity confers resistance to 5-bromodeoxyuridine toxicity and mutagenesis.
Next Document:  Effect of 3-aminobenzamide on the process of ultraviolet-induced DNA excision repair.