Document Detail


Analysis of sister-chromatid exchanges (SCEs) in familial and sporadic multiple sclerosis.
MedLine Citation:
PMID:  3702896     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The levels of sister-chromatid exchanges (SCEs) were calculated in 17 multiple sclerosis (MS) patients (14 familial and 3 sporadic cases) and 16 healthy controls matched for sex and age. The SCEs were significantly increased for MS patients (p = 0.0002), while there was no statistically significant difference between men and women and between younger and older subjects in both groups. Such factors as familial occurrence and severity of MS, smoking habits, and distribution of lymphocyte subpopulations were discussed. Although there was a significant difference between the MS patients taking medication and the patients taking none (p = 0.038), the latter were still significantly different from the controls (p = 0.035), supporting the fact that the disease itself increases SCEs. Our study, done with 2 doses of BrdU, also shows that the increased SCEs in MS patients are not due to a hypersensitivity to this substance known to be an inducer of SCEs. Thus we suggest that the increased SCEs found are probably disease-related.
Authors:
M Senécal-Quevillon; P Duquette; C L Richer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  161     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-06-20     Completed Date:  1986-06-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  65-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Cells, Cultured
Female
Humans
Lymphocytes / cytology
Male
Metaphase
Middle Aged
Multiple Sclerosis / genetics*,  physiopathology
Reference Values
Sex Factors
Sister Chromatid Exchange*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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