Document Detail


Analysis of the significance of a periodic, cell size-controlled doubling in rates of macromolecular synthesis for the control of balanced exponential growth of fission yeast cells.
MedLine Citation:
PMID:  422679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mutant strains of the fission yeast Schizosaccharomyces pombe are available which divide at smaller mean sizes than wild type. Earlier work by the present authors has shown that all these strains double their rates of polyadenylated messenger RNA synthesis as a step once in each cell cycle. The smaller the cell, the later in the cycle is the doubling in rate of synthesis. Strains of all sizes, however, double their synthetic rate when at the same threshold size. We show here that the differences in cell cycle stage of doubling in rate of polyadenylated messenger RNA synthesis are enough to explain the reduced mean steady state polyadenylated messenger RNA contents of the smaller strains. The cell size-related control over doubling in rate of synthesis is also shown to maintain the mean polyadenylated messenger RNA content as a constant proportion of cell mass, irrespective of cell size. This control thus allows cells to maintain balanced exponential growth, even when absolute growth rate per cell is altered by mutation. It is also shown that the concentration of polyadenylated messenger RNA itself could act as a monitor of the threshold size triggering the doubling in rate of synthesis in each cell cycle.
Authors:
A Barnes; P Nurse; R S Fraser
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cell science     Volume:  35     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-05-26     Completed Date:  1979-05-26     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ascomycota / metabolism*
Cell Cycle
Cell Division
Kinetics
Mutation
Poly A / metabolism
RNA, Messenger / biosynthesis*
Schizosaccharomyces / cytology,  growth & development,  metabolism*
Chemical
Reg. No./Substance:
0/RNA, Messenger; 24937-83-5/Poly A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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