Document Detail


Analysis of shape and positioning of the hippocampal formation: an MRI study in patients with partial epilepsy and healthy controls.
MedLine Citation:
PMID:  16014649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to evaluate systematically shape and positioning of the hippocampal formation (HF) in patients with partial epilepsy related to malformations of cortical development (MCD) and those with temporal lobe epilepsy (TLE). We studied 76 patients with MCD, including focal cortical dysplasia (n = 29; lesions located outside the temporal lobe in all), heterotopia (lesions outside of the temporal lobe, n = 14; lesions extending into the temporal lobe, n = 16), polymicrogyria (bilateral perisylvian, n = 14; unilateral perisylvian, n = 3) and 30 patients with TLE (hippocampal atrophy, n = 15; normal hippocampal volumes, n = 15). Shape and positioning of the HF were evaluated using a set of eight predefined morphological characteristics. In addition, the degree of hippocampal vertical orientation and medial positioning were assessed quantitatively. Patients were compared with 50 healthy controls. At least three criteria describing abnormal HF shape and positioning were found in 5/50 (10%) healthy controls, 37/76 (49%) MCD and 13/30 (43%) TLE patients. An association with all criteria was found in MCD and TLE, but not in healthy controls. In MCD there was no association between the side of HF shape abnormalities and the side of the cortical malformation or the EEG focus. Likewise, in TLE, HF abnormalities were not related to the side of the EEG focus. In both MCD and TLE patients who had hippocampal atrophy, no association was found between the side of HF shape abnormalities and the side of atrophy. Abnormal HF shape and positioning are found in a similar proportion in MCD and TLE. In TLE, they may be a marker of a more extensive disorder of brain development and may participate in the development of this condition.
Authors:
N Bernasconi; D Kinay; F Andermann; S Antel; A Bernasconi
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Publication Detail:
Type:  Journal Article     Date:  2005-07-13
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  128     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-26     Completed Date:  2005-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  2442-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology and Brain Imaging Center, McGill University, Montreal Neurological Institute and Hospital, Montreal, Quebec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Atrophy
Cerebral Cortex / abnormalities,  pathology
Choristoma / pathology
Electroencephalography / methods
Epilepsies, Partial / pathology*
Epilepsy, Temporal Lobe / pathology
Female
Hippocampus / growth & development,  pathology*
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Temporal Lobe / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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