| Analysis of serum cytokine/chemokine profiles affected by aging and exercise in mice. | |
| | |
MedLine Citation:
|
PMID: 22884519 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Aging could be the cause of inflammation involved in the progression of many degenerative diseases while physical exercise might reduce the inflammation. This study examined the effects of aging versus exercise on serum profiles of cytokines and chemokines in mice models. Male C57BL/6N mice with different ages (2 and 20months old) were subjected to treadmill exercise for 4weeks. The exercise did not affect the body mass gain of the young mice but significantly reduced that of the old mice. Of 50 cytokines/chemokines analyzed using a multiplexed bead-based sandwich immunoassay, Eotaxin, Interleukin-9 and Thymus and activation-related chemokine showed significantly higher serum levels in old mice compared with young mice (p<0.05). The treadmill exercise did not alter serum cytokines/chemokines levels significantly. This study suggests that the cytokines and chemokines, whose serum levels were changed age-dependently, would provide useful markers of the systemic low-level inflammation associated with aging and age-related diseases. |
| | |
Authors:
|
Hyeona Jeon; Gyeong In Mun; Yong Chool Boo |
Related Documents
:
|
22706949 - Vo2 responses to running speeds above intermittent critical speed. 12372309 - Achilles tendinopathy. 16412929 - Determination of aqueous and vitreous concentration of moxifloxacin 0.5% after delivery... 22538549 - Gross efficiency and energy expenditure in kayak ergometer exercise. 21838199 - Pulmonary rehabilitation in resource poor settings. 12937029 - Effect of habitual running on human achilles tendon load-deformation properties and cro... 22108669 - Prefrontal cortex transcranial direct current stimulation associated with aerobic exerc... 16619099 - Reduced quadriceps activation after lumbar paraspinal fatiguing exercise. 21399959 - Increase in serum growth hormone induced by electrical stimulation of muscle combined w... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-8-9 |
Journal Detail:
|
Title: Cytokine Volume: - ISSN: 1096-0023 ISO Abbreviation: Cytokine Publication Date: 2012 Aug |
Date Detail:
|
Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9005353 Medline TA: Cytokine Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Medical Education Program for Human Resources, Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Microscopic nodes and ducts inside lymphatics and on the surface of internal organs are rich in gran...
Next Document: Oxysterol generation and liver X receptor-dependent reverse cholesterol transport: Not all roads lea...