Document Detail


Analysis of serum cytokine/chemokine profiles affected by aging and exercise in mice.
MedLine Citation:
PMID:  22884519     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aging could be the cause of inflammation involved in the progression of many degenerative diseases while physical exercise might reduce the inflammation. This study examined the effects of aging versus exercise on serum profiles of cytokines and chemokines in mice models. Male C57BL/6N mice with different ages (2 and 20months old) were subjected to treadmill exercise for 4weeks. The exercise did not affect the body mass gain of the young mice but significantly reduced that of the old mice. Of 50 cytokines/chemokines analyzed using a multiplexed bead-based sandwich immunoassay, Eotaxin, Interleukin-9 and Thymus and activation-related chemokine showed significantly higher serum levels in old mice compared with young mice (p<0.05). The treadmill exercise did not alter serum cytokines/chemokines levels significantly. This study suggests that the cytokines and chemokines, whose serum levels were changed age-dependently, would provide useful markers of the systemic low-level inflammation associated with aging and age-related diseases.
Authors:
Hyeona Jeon; Gyeong In Mun; Yong Chool Boo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  Cytokine     Volume:  -     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Molecular Medicine, Cell and Matrix Research Institute, BK21 Medical Education Program for Human Resources, Kyungpook National University School of Medicine, Daegu 700-422, Republic of Korea.
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