Document Detail

Analysis of serotonin, dopamine and their metabolites in the caudate putamen, the suprachiasmatic nucleus and the median raphe nucleus of euthermic and torpid deermice, Peromyscus maniculatus.
MedLine Citation:
PMID:  2813470     Owner:  NLM     Status:  MEDLINE    
Deermice, subjected to food rationing and low ambient temperature, were sacrificed in normothermia or during daily torpor. Levels of monoamines and their metabolites in the caudate putamen (CPN), the suprachiasmatic nuclear area (SCN), and the median raphe nucleus (MRN) were quantified through the use of HPLC with electrochemical detection. Significant elevations in levels (pg/mg protein) of the serotonin (5-HT) metabolite, 5-hydroxyindole-3-acetic acid (5-HIAA) were noted in torpid individuals in all nuclei examined. The dopamine (DA) metabolite, homovanillic acid (HVA) was significantly elevated in the CPN and MRN of torpid individuals. Moreover, a significant increase in the HVA to DA ratio was also noted in the CPN and the MRN. In the SCN, the concentrations of 5-hydroxytryptophan (5-HTP), 5-HT, DA and 3,4-dihydroxyphenylacetic acid (DOPAC) were also increased significantly during torpor. These significant elevations suggest that an increase in the activity of the serotonergic and dopaminergic systems occurs in these nuclei during daily torpor in the deermouse.
L H Lin; E B Pivorun
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  33     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-12-19     Completed Date:  1989-12-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  309-14     Citation Subset:  IM    
Clemson University, Department of Biological Sciences, SC 29634-1903.
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MeSH Terms
Behavior, Animal / physiology*
Brain / metabolism*
Brain Chemistry*
Caudate Nucleus / analysis,  metabolism
Cold Temperature
Dopamine / analysis*,  metabolism
Food Deprivation / physiology
Peromyscus / metabolism*
Putamen / analysis,  metabolism
Raphe Nuclei / analysis,  metabolism
Serotonin / analysis*,  metabolism
Suprachiasmatic Nucleus / analysis,  metabolism
Grant Support
Reg. No./Substance:

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