| Analysis of serial coronary artery flow patterns early after primary angioplasty: new insights into the dynamics of the microcirculation. | |
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MedLine Citation:
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PMID: 18669143 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The temporal behavior of the coronary microcirculation in acute myocardial infarction may affect outcome. Diastolic deceleration time and early systolic flow reversal derived from coronary artery blood flow velocity patterns reflect microcirculatory function. OBJECTIVES: To assess left anterior descending coronary artery flow velocity patterns using Doppler transthoracic echocardiography after primary percutaneous coronary intervention, in patients with anterior AMI. METHODS: Patterns of flow velocity patterns of the LAD were obtained using transthoracic echocardiography-Doppler in 31 consecutive patients who presented with anterior AMI. Measurements were done at 6 hours, 36-48 hours, and 5 days after successful PPCI. Measurements of DDT and pressure half times (Pt%), as well as observation for ESFR were performed. RESULTS: In the first 2 days following PPCI, the average DDT (600 +/- 340 msec) was shorter than on day 5 (807 +/- 332 msec) (P < 0.012), FVP in the first 2 days were dynamic and bidirectional: from short DDT (< 600 msec) to long DDT (> 600 msec) and vice versa. On day 5 most DDTs became longer. Pt1/2 at 6 hours was not different than at day 2 (174 +/- 96 vs. 193 +/- 99 msec, P = NS) and became longer on day 5 (235 +/- 98 msec, P = 0.012). Bidirectional patterns were also observed in the ESFR in 6 patients (19%) at baseline, in 4 (13%) at 36 hours, and in 2 (6.5%) on day 5 after PPCI. CONCLUSIONS: Flow velocity patterns of the LAD after PPCI in AMI are dynamic and reflect unpredictable changes in microcirculation. |
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Authors:
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Dawod Sharif; Guy Rofe; Amal Sharif-Rasslan; Ehud Goldhammer; Nabeel Makhoul; Arie Shefer; Amin Hassan; Shmuel Rauchfleisch; Uri Rosenschein |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Israel Medical Association journal : IMAJ Volume: 10 ISSN: 1565-1088 ISO Abbreviation: Isr. Med. Assoc. J. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-08-01 Completed Date: 2008-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100930740 Medline TA: Isr Med Assoc J Country: Israel |
Other Details:
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Languages: eng Pagination: 440-4 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Bnai Zion Medical Center, and Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. dawod.sharif@b-zion.org.il |
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| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary* Blood Flow Velocity Coronary Artery Disease / physiopathology Coronary Circulation* Coronary Vessels / physiopathology*, ultrasonography Echocardiography, Doppler Female Hemodynamics* Humans Male Microcirculation Middle Aged Myocardial Infarction / physiopathology Prospective Studies Risk Factors |
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