Document Detail

Analysis of the rpn11-m1 proteasomal mutant reveals connection between cell cycle and mitochondrial biogenesis.
MedLine Citation:
PMID:  21059189     Owner:  NLM     Status:  In-Data-Review    
The proteasomal lid subunit Rpn11 is essential for maintaining a correct cell cycle and mitochondrial morphology in Saccharomyces cerevisiae. In this paper, we show that the rpn11-m1 mutant has a peculiar cell cycle defect reminiscent of mutants defective in the FEAR pathway that delay the release of the Cdc14 protein phosphatase from the nucleolus. We analyzed the rpn11-m1 phenotypes and found that overexpression of Cdc14 suppresses all the rpn11-m1 defects, including the mitochondrial ones. Suppression by Cdc14 of the rpn11-m1 mitochondrial morphology defect reveals an uncharacterized connection between mitochondrial and cell cycle events. Interestingly, the overexpression of Cdc14 also partially restores the tubular network in an Δmmm2 strain, which lacks a mitochondrial protein belonging to the complex necessary to anchor the mitochondrion to the actin cytoskeleton. Altogether our findings indicate, for the first time, a cross-talk between the cell cycle and mitochondrial morphology.
Michela Esposito; Simonetta Piatti; Line Hofmann; Laura Frontali; Agnès Delahodde; Teresa Rinaldi
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Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  FEMS yeast research     Volume:  11     ISSN:  1567-1364     ISO Abbreviation:  FEMS Yeast Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101085384     Medline TA:  FEMS Yeast Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  60-71     Citation Subset:  IM    
Copyright Information:
© 2010 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.
Department of Cell and Developmental Biology, Pasteur Institute-Cenci Bolognetti Foundation, University of Rome, Rome, Italy Dipartimento di Biotecnologie e Bioscienze, Universitá di Milano-Bicocca, Milan, Italy Université Paris-Sud, CNRS-UMR8621, Orsay, France.
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