| Analysis of the role of angiotensinogen in spontaneous hypertension. | |
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MedLine Citation:
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PMID: 7768569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Allelic variants at the human angiotensinogen locus have recently been reported to increase susceptibility to the development of essential hypertension. In this study we analyzed the role played by angiotensinogen in the elevated blood pressure of the spontaneously hypertensive rat (SHR). The SHR angiotensinogen locus (on chromosome 19) cosegregated with a significant (P = .003) and specific increase in pulse pressure in F2 rats derived from a cross of the SHR with the normotensive Wistar-Kyoto rat (WKY), accounting for 20% of the genetic (10% of total) variance in this phenotype. To identify potential mechanisms underlying the effect of the locus, we further examined angiotensinogen structure and expression in the two strains. Sequence analysis of the respective coding regions revealed no differences in the primary structure of angiotensinogen between the strains. Likewise, plasma angiotensinogen level did not differ in adult rats of the two strains. However, gene expression studies showed tissue-specific, age-related differences in angiotensinogen mRNA levels between SHR and WKY, particularly in the aorta. The findings suggest that pulse pressure, which significantly influences cardiovascular risk, has independent genetic determinants. They further suggest that the effect of the angiotensinogen locus on this phenotype in the SHR may be mediated through a tissue-specific abnormality of angiotensinogen gene expression. |
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Authors:
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D Lodwick; M A Kaiser; J Harris; F Cumin; M Vincent; N J Samani |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 25 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1995 Jun |
Date Detail:
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Created Date: 1995-06-30 Completed Date: 1995-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1245-51 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Leicester, Leicester Royal Infirmary, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensinogen
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blood,
genetics,
physiology* Animals Base Sequence Chromosome Mapping Female Genotype Hypertension / etiology*, genetics Male Molecular Sequence Data Polymorphism, Restriction Fragment Length RNA, Messenger / analysis Rats Rats, Inbred SHR Rats, Inbred WKY Renin / blood |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 11002-13-4/Angiotensinogen; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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