Document Detail

Analysis of responses to sarafotoxin 6a and sarafotoxin 6c in the pulmonary vascular bed of the cat.
MedLine Citation:
PMID:  1761504     Owner:  NLM     Status:  MEDLINE    
Pulmonary vascular responses to sarafotoxins 6a and 6c (S6a and S6c) were investigated in the intact-chest cat under constant flow conditions. Injections of S6a and S6c into the perfused lobar artery caused dose-related increases in lobar arterial pressure, increased left atrial pressure, and produced biphasic changes in systemic arterial (aortic) pressure. When left atrial pressure was maintained constant, injections of S6a, S6c, and endothelin 1 (ET-1) caused dose-related increases in lobar arterial pressure. The increases in lobar arterial pressure in response to S6a and S6c were not altered by treatment with a cyclooxygenase inhibitor or a thromboxane receptor blocking agent. Increases in lobar arterial pressure in response to S6a and S6c were not altered when airflow to the left lower lung lobe was interrupted by bronchial occlusion, and pressor responses were not diminished when the left lower lobe was perfused with low-molecular-weight dextran. Under conditions of controlled blood flow and constant left atrial pressure, S6a, S6b, S6c, and ET-1 had similar pressor activity, whereas the thromboxane A2 mimic, U-46619, had far greater activity when compared on a nanomolar basis. The present studies demonstrate that S6a and S6c have significant vasoconstrictor activity in the feline pulmonary vascular bed. These data suggest that pulmonary vasoconstrictor responses to the endothelin peptides are not dependent on release of cyclooxygenase products and the activation of thromboxane A2 receptors, alterations in bronchomotor tone, or interaction with formed elements in blood.
T J McMahon; J S Hood; P J Kadowitz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  71     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1991 Nov 
Date Detail:
Created Date:  1992-02-07     Completed Date:  1992-02-07     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2019-25     Citation Subset:  IM    
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112.
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MeSH Terms
Amino Acid Sequence
Blood Pressure / drug effects
Endothelins / chemistry
Molecular Sequence Data
Prostaglandin-Endoperoxide Synthases / metabolism
Pulmonary Circulation / drug effects*,  physiology
Respiration, Artificial
Sequence Homology, Nucleic Acid
Thromboxane A2 / antagonists & inhibitors,  biosynthesis
Vasoconstriction / drug effects
Viper Venoms / chemistry,  pharmacology*
Grant Support
Reg. No./Substance:
0/Endothelins; 0/Viper Venoms; 0/sarafotoxins s6; 57576-52-0/Thromboxane A2; EC Synthases

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