Document Detail

Analysis of the relationship between sex and chromosomal aberrations in colorectal cancer by comparative genomic hybridization.
MedLine Citation:
PMID:  16989496     Owner:  NLM     Status:  MEDLINE    
Colorectal cancer is thought to be more common in men than in women. The chromosomal locations of DNA gains and losses in surgical specimens of colorectal tumours were detected by comparative genomic hybridization and were compared by gender. Five chromosomal regions, 7p, 8p, 8q, Xp and Xq, contained multiple gains that were significantly more common in males than in females, and within these regions, the differences were significant for Xp21, Xp11.3, Xp11.4 and Xq26. Regions 1p, 3q, 11q, 12p, 12q and 15q contained multiple sites of gain that were significantly more common in females than in males. Tumours from male and female patients showed significantly more losses at 11p and 15q, and at 4q and Xq, respectively. The fact that gains in X-chromosomal regions were detected with a significantly higher frequency in tumours from male patients suggests that the difference between the genders might be explained by X-chromosomal inactivation.
J Unotoro; H Kamiyama; Y Ishido; Y Yaginuma; S Kasamaki; K Sakamoto; A Oota; Y Ishibashi; T Kamano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of international medical research     Volume:  34     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2006 Jul-Aug
Date Detail:
Created Date:  2006-09-22     Completed Date:  2006-10-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-405     Citation Subset:  IM    
Department of Coloproctological Surgery, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Adenocarcinoma / genetics*,  pathology
Aged, 80 and over
Chromosome Aberrations*
Chromosomes, Human, X / genetics*
Colorectal Neoplasms / genetics*,  pathology
Gene Amplification
Gene Dosage
In Situ Hybridization, Fluorescence*
Middle Aged
Sex Characteristics

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