Document Detail


Analysis of relation between virologic responses and immunologic responses, patient's factors in AIDS clinical trials using a semiparametric mixed-effects model.
MedLine Citation:
PMID:  17623345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this article we propose to use a semiparametric mixed-effects model based on an exploratory analysis of clinical trial data for a study of the relation between virologic responses and immunologic markers such as CD4+ and CD8 counts, and host-specific factors in AIDS clinical trials. The regression spline technique, used for inference for parameters in the model, reduces the unknown nonparametric components to parametric functions. It is simple and straightforward to implement the procedures using readily available software, and parameter inference can be developed from standard parametric models. We apply the model and the proposed method to an AIDS clinical study. Our findings indicate that viral load level is positively related to baseline viral load level, negatively related to CD4+ cell counts, but unrelated to CD8 cell counts and patient's age neither.
Authors:
Hua Liang; Guohua Zou
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biometrical journal. Biometrische Zeitschrift     Volume:  49     ISSN:  0323-3847     ISO Abbreviation:  Biom J     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-17     Completed Date:  2007-08-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7708048     Medline TA:  Biom J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  406-15     Citation Subset:  IM    
Affiliation:
Department of Biostatistics and Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 630, Rochester, NY 14642, USA. hliang@bst.rochester.edu
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MeSH Terms
Descriptor/Qualifier:
Acquired Immunodeficiency Syndrome / drug therapy*,  immunology,  virology
Antiviral Agents / therapeutic use*
CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes / immunology
Clinical Trials, Phase I as Topic
Clinical Trials, Phase II as Topic
HIV / immunology
Humans
Models, Biological*
Randomized Controlled Trials as Topic / statistics & numerical data*
Viral Load
Grant Support
ID/Acronym/Agency:
AI59773/AI/NIAID NIH HHS; AI62247/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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