| Analysis of regional cerebral blood flow in dogs, with an experimental microbubble-based US contrast agent. | |
| | |
MedLine Citation:
|
PMID: 8816531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To evaluate a perfluorochemical stabilized microbubble-based ultrasound (US) contrast agent (Imagent US, formulation AF0145) create regional cerebral blood flow (CBF) maps. MATERIALS AND METHODS: Intravenous injections of the contrast agent (0.16-0.20 mL/kg) were performed in four anesthetized dogs (9-14 kg). Serial coronal color-Doppler-amplitude and gray-scale US scans were obtained through a cranial window during injection of contrast material. Mean pixel intensity was analyzed on digitized images. Regional CBF was varied by modifying arterial partial pressure of carbon dioxide (PaCO2). Color-Doppler-amplitude and gray-scale mean pixel intensity and percentage change in mean pixel intensity after injection of contrast material were analyzed, by means of a bolus injection curve that plotted color mean pixel intensity per unit area versus time. RESULTS: Contrast material injection resulted in a statistically significant difference in color-Doppler-amplitude and gray-scale enhancement of brain. Color mean pixel intensity increased from 1.4 units +/- 1 (standard error) to 122 units +/- 6 in thalamus and from 9.7 units +/- 4.0 to 107 units +/- 9 in cortex (P < .0001). Gray-scale mean pixel intensity increased from 0.55 units +/- 0.20 to 33 units +/- 11 in thalamus and from 0.42 units +/- .06 to 10.5 units +/- 2.0 in cortex (P < .005). Correlation between the area under the color-Doppler-amplitude mean-pixelintensity curve and regional CBF in thalamus and cortex was significant (r = .815, P < .0001). CONCLUSION: Color-Doppler-amplitude US can be used to create regional CBF maps and shows potential for noninvasive evaluation of CBF in the critically ill newborn. |
| | |
Authors:
|
R S Greenberg; G A Taylor; J C Stapleton; C A Hillsley; D Spinak |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Radiology Volume: 201 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1996 Oct |
Date Detail:
|
Created Date: 1996-10-28 Completed Date: 1996-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 119-23 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cerebrovascular Circulation / physiology* Contrast Media* Dogs Fluorocarbons / diagnostic use* Ultrasonography, Doppler, Transcranial / methods* |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Fluorocarbons; 0/Imagent US |
| Comments/Corrections | |
Comment In:
|
Radiology. 1997 Jul;204(1):279-81
[PMID:
9205261
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of fetal midface anatomy related to facial clefts: use of US.
Next Document: Renal cortical perfusion in rabbits: visualization with color amplitude imaging and an experimental ...