Document Detail

Analysis of reciprocal creatinine plots by two-phase linear regression.
MedLine Citation:
PMID:  2655448     Owner:  NLM     Status:  MEDLINE    
The progression of renal diseases is often monitored by the serial measurement of plasma creatinine. The slope of the linear relation that is frequently found between the reciprocal of creatinine concentration and time delineates the rate of change in renal function. Minor changes in slope, perhaps indicating response to therapeutic intervention, can be difficult to identify and yet be of clinical importance. We describe the application of two-phase linear regression to identify and characterise changes in slope using a microcomputer. The method fits two intersecting lines to the data by computing a least-squares estimate of the position of the slope change and its 95% confidence limits. This avoids the potential bias of fixing the change at a preconceived time corresponding with an alteration in treatment. The program then evaluates the statistical and clinical significance of the slope change and produces a graphical output to aid interpretation.
P A Rowe; R E Richardson; P R Burton; A G Morgan; R P Burden
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of nephrology     Volume:  9     ISSN:  0250-8095     ISO Abbreviation:  Am. J. Nephrol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-12     Completed Date:  1989-06-12     Revised Date:  2007-02-14    
Medline Journal Info:
Nlm Unique ID:  8109361     Medline TA:  Am J Nephrol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  38-43     Citation Subset:  IM    
Renal Unit, City Hospital, Nottingham, UK.
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MeSH Terms
Creatinine / diagnostic use*
Diagnosis, Computer-Assisted*
Kidney Failure, Chronic / diagnosis*
Kidney Function Tests*
Programming Languages
Regression Analysis
Reg. No./Substance:

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