| Analysis of reciprocal creatinine plots by two-phase linear regression. | |
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MedLine Citation:
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PMID: 2655448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The progression of renal diseases is often monitored by the serial measurement of plasma creatinine. The slope of the linear relation that is frequently found between the reciprocal of creatinine concentration and time delineates the rate of change in renal function. Minor changes in slope, perhaps indicating response to therapeutic intervention, can be difficult to identify and yet be of clinical importance. We describe the application of two-phase linear regression to identify and characterise changes in slope using a microcomputer. The method fits two intersecting lines to the data by computing a least-squares estimate of the position of the slope change and its 95% confidence limits. This avoids the potential bias of fixing the change at a preconceived time corresponding with an alteration in treatment. The program then evaluates the statistical and clinical significance of the slope change and produces a graphical output to aid interpretation. |
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Authors:
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P A Rowe; R E Richardson; P R Burton; A G Morgan; R P Burden |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of nephrology Volume: 9 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-06-12 Completed Date: 1989-06-12 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 38-43 Citation Subset: IM |
Affiliation:
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Renal Unit, City Hospital, Nottingham, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Creatinine / diagnostic use* Diagnosis, Computer-Assisted* Humans Kidney Failure, Chronic / diagnosis* Kidney Function Tests* Male Microcomputers Programming Languages Regression Analysis |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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