Document Detail

Analysis of rat brain microdialysate by gas chromatography-high-resolution selected-ion monitoring mass spectrometry.
MedLine Citation:
PMID:  1709174     Owner:  NLM     Status:  MEDLINE    
Gas chromatography-high-resolution selected-ion monitoring mass spectrometry was used to analyze catecholamine metabolites in rat brain microdialysate. Dialysate samples were collected in vials containing stable isotope analogues of homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxyindoleacetic acid (5HIAA) and analyzed as their trimethylsilyl derivatives. The metabolite levels were monitored at 20-min intervals throughout the time course of the experiment, beginning immediately after surgery and implantation of the dialysis probe and ending 4 h after amphetamine treatment. The levels of HVA were observed to decrease after amphetamine treatment, while those of MHPG and 5HIAA did not change significantly.
S Y Chang; T A Moore; L L Devaud; L C Taylor; E B Hollingsworth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  562     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-06-10     Completed Date:  1991-06-10     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-8     Citation Subset:  IM    
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MeSH Terms
Amphetamine / pharmacology
Brain Chemistry* / drug effects
Catecholamines / analysis*
Gas Chromatography-Mass Spectrometry
Homovanillic Acid / analysis
Hydroxyindoleacetic Acid / analysis
Methoxyhydroxyphenylglycol / analysis
Rats, Inbred Strains
Reg. No./Substance:
0/Catecholamines; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; CK833KGX7E/Amphetamine; X77S6GMS36/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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