Document Detail

Analysis of radon-induced lung cancer risk by a stochastic state-vector model of radiation carcinogenesis.
MedLine Citation:
PMID:  12400949     Owner:  NLM     Status:  MEDLINE    
A biologically based state-vector model (SVM) of radiation carcinogenesis has been extended to incorporate stochasticity of cellular transitions and specific in vivo irradiation conditions in the lungs. Dose-rate-dependent cellular transitions related to the formation of double-stranded DNA breaks, repair of breaks, interactions (translocations) between breaks, fixation of breaks, cellular inactivation, stimulated mitosis and promotion through loss of intercellular communication are simulated by Monte Carlo methods. The stochastic SVM has been applied to the analysis of lung cancer incidence in uranium miners exposed to alpha-emitting radon progeny. When incorporating in vivo features of cell differentiation, stimulated cell division and heterogeneity of cellular doses into the model, excellent agreement between epidemiological data and modelling results could be obtained. At low doses, the model predicts a nonlinear dose-response relationship; e.g., computed lung cancerrisk at 20WLM is about half of current lung cancer estimates based on the linear hypothesis. The model also predicts a slight dose rate effect; e.g., at a cumulative exposure of 20 WLM, calculated lung cancer incidence for an exposure rate 0.27 WLM/year (assuming an exposure time of 73 years) is smaller by a factor of 1.2 than that for an exposure rate of 10 WLM/year.
Douglas J Crawford-Brown; Werner Hofmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of radiological protection : official journal of the Society for Radiological Protection     Volume:  22     ISSN:  0952-4746     ISO Abbreviation:  J Radiol Prot     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-10-28     Completed Date:  2003-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809257     Medline TA:  J Radiol Prot     Country:  England    
Other Details:
Languages:  eng     Pagination:  A61-5     Citation Subset:  IM    
Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, 27599-1105, USA.
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MeSH Terms
Air Pollutants, Occupational / adverse effects*
Air Pollutants, Radioactive / adverse effects*
Cell Division / radiation effects
DNA Damage / radiation effects
Dose-Response Relationship, Radiation
Lung Neoplasms / etiology*
Models, Statistical
Neoplasms, Radiation-Induced / etiology*
Occupational Diseases / etiology*
Radiation Dosage
Radon / adverse effects*
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Air Pollutants, Radioactive; 10043-92-2/Radon; 7440-61-1/Uranium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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