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Analysis of pulse wave velocity in the thoracic aorta by flow-sensitive four-dimensional MRI: Reproducibility and correlation with characteristics in patients with aortic atherosclerosis.
MedLine Citation:
PMID:  22271330     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To measure aortic pulse wave velocity (PWV) using flow-sensitive four-dimensional (4D) MRI and to evaluate test-retest reliability, inter- and intra-observer variability in volunteers and correlation with characteristics in patients with aortic atherosclerosis. MATERIALS AND METHODS: Flow-sensitive 4D MRI was performed in 12 volunteers (24 ± 3 years) and 86 acute stroke patients (68 ± 9 years) with aortic atherosclerosis. Retrospectively positioned 28 ± 4 analysis planes along the entire aorta (inter-slice-distance = 10 mm) and frame wise lumen segmentation yielded flow-time-curves for each plane. Global aortic PWV was calculated from time-shifts and distances between the upslope portions of all available flow-time curves. RESULTS: Inter- and intra-observer variability of PWV measurements in volunteers (7% and 8%) was low while test-retest reliability (22%) was moderate. PWV in patients was significantly higher compared with volunteers (5.8 ± 2.9 versus 3.8 ± 0.8 m/s; P = 0.02). Among 17 patient characteristics considered, statistical analysis revealed significant (P < 0.05) but low correlation of PWV with age (r = 0.25), aortic valve insufficiency (r = 0.29), and pulse pressure (r = 0.28). Multivariate modeling indicated that aortic valve insufficiency and elevated pulse pressure were significantly associated with higher PWV (adjusted R(2) = 0.13). CONCLUSION: Flow-sensitive 4D MRI allows for estimating aortic PWV with low observer dependence and moderate test-retest reliability. PWV in patients correlated with age, aortic valve insufficiency, and pulse pressure. J. Magn. Reson. Imaging 2012;. © 2012 Wiley Periodicals, Inc.
Authors:
Michael Markl; Wolf Wallis; Christoph Strecker; Beryl Primrose Gladstone; Werner Vach; Andreas Harloff
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-23
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  -     ISSN:  1522-2586     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Radiology, Medical Physics, University Medical Center Freiburg, Germany; Departments of Radiology and Biomedical Engineering, Northwestern University, Chicago, USA. mmarkl@northwestern.edu.
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