| Analysis and prediction of mammalian protein glycation. | |
| | |
MedLine Citation:
|
PMID: 16762979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Glycation is a nonenzymatic process in which proteins react with reducing sugar molecules and thereby impair the function and change the characteristics of the proteins. Glycation is involved in diabetes and aging where the accumulation of glycation products causes side effects. In this study, we statistically investigate the glycation of epsilon amino groups of lysines and also train a sequence-based predictor. The statistical analysis suggests that acidic amino acids, mainly glutamate, and lysine residues catalyze the glycation of nearby lysines. The catalytic acidic amino acids are found mainly C-terminally from the glycation site, whereas the basic lysine residues are found mainly N-terminally. The predictor was made by combining 60 artificial neural networks in a balloting procedure. The cross-validated Matthews correlation coefficient for the predictor is 0.58, which is quite impressive given the relatively small amount of experimental data available. The method is made available at www.cbs.dtu.dk/services/NetGlycate-1.0. |
| | |
Authors:
|
Morten Bo Johansen; Lars Kiemer; Søren Brunak |
Related Documents
:
|
1465449 - Genomic structure of the human caldesmon gene. 11805319 - Gene characterized for membrane desaturase that produces (e)-11 isomers of mono- and di... 1717589 - Mutational analysis of the cross-reactive idiotype of the a strain mouse. 12139969 - Purification and characterization of a novel glutathione s-transferase from asaphis dic... 8580769 - Purification and characterisation of soluble invertases from leaves of arabidopsis thal... 23359009 - Use of multi-parameter flow cytometry as tool to monitor the impact of formic acid on s... 12727259 - Selective optimization in thermophilic acidogenesis of cheese-whey wastewater to acetic... 11171629 - Esophagitis-related esophageal shortening in opossum is associated with longitudinal mu... 16657199 - Regulation of sulfate uptake by amino acids in cultured tobacco cells. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-08 |
Journal Detail:
|
Title: Glycobiology Volume: 16 ISSN: 0959-6658 ISO Abbreviation: Glycobiology Publication Date: 2006 Sep |
Date Detail:
|
Created Date: 2006-08-18 Completed Date: 2006-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9104124 Medline TA: Glycobiology Country: England |
Other Details:
|
Languages: eng Pagination: 844-53 Citation Subset: IM |
Affiliation:
|
Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Databases, Protein Humans Internet Neural Networks (Computer)* Protein Modification, Translational / genetics* Proteins / genetics* Proteome / genetics* Sequence Analysis, Protein* / methods Software* |
| Chemical | |
Reg. No./Substance:
|
0/Proteins; 0/Proteome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role of nitric oxide in high glucose-induced mitogenic response in renal fibroblasts.
Next Document: Identification of core 1 O-glycan T-synthase from Caenorhabditis elegans.