Document Detail


Analysis and prediction of mammalian protein glycation.
MedLine Citation:
PMID:  16762979     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycation is a nonenzymatic process in which proteins react with reducing sugar molecules and thereby impair the function and change the characteristics of the proteins. Glycation is involved in diabetes and aging where the accumulation of glycation products causes side effects. In this study, we statistically investigate the glycation of epsilon amino groups of lysines and also train a sequence-based predictor. The statistical analysis suggests that acidic amino acids, mainly glutamate, and lysine residues catalyze the glycation of nearby lysines. The catalytic acidic amino acids are found mainly C-terminally from the glycation site, whereas the basic lysine residues are found mainly N-terminally. The predictor was made by combining 60 artificial neural networks in a balloting procedure. The cross-validated Matthews correlation coefficient for the predictor is 0.58, which is quite impressive given the relatively small amount of experimental data available. The method is made available at www.cbs.dtu.dk/services/NetGlycate-1.0.
Authors:
Morten Bo Johansen; Lars Kiemer; Søren Brunak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-08
Journal Detail:
Title:  Glycobiology     Volume:  16     ISSN:  0959-6658     ISO Abbreviation:  Glycobiology     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-18     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104124     Medline TA:  Glycobiology     Country:  England    
Other Details:
Languages:  eng     Pagination:  844-53     Citation Subset:  IM    
Affiliation:
Center for Biological Sequence Analysis, BioCentrum-DTU, Technical University of Denmark, Building 208, DK-2800 Lyngby, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Databases, Protein
Humans
Internet
Neural Networks (Computer)*
Protein Modification, Translational / genetics*
Proteins / genetics*
Proteome / genetics*
Sequence Analysis, Protein* / methods
Software*
Chemical
Reg. No./Substance:
0/Proteins; 0/Proteome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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