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Analysis for post-transplant changes of peripheral lymphocyte subsets in liver transplant receptors with HBV infection.
MedLine Citation:
PMID:  21722535     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: To investigate the characters and changes of peripheral lymphocyte subsets and cytokines in liver transplant receptors with HBV infection in short phases after liver transplantation, and to provide evidences for monitoring post-transplant immune condition of liver transplant receptors. METHODS: Peripheral lymphocyte subsets and cytokine levels in pre- and post- transplant 12 h, 3 d, 10 d, 30 d, 60 d of 20 cases of patients with HBV-associated severe hepatic diseases were investigated and analyzed, and were compared respectively with those of 22 cases of healthy adults as control (HC) with flow cytometry (FCM) and ELISA. RESULTS: The patients' accounts of peripheral lymphocyte subsets before liver transplantation were lower than those of HC significantly, but the accounts decreased significantly after transplantation 12 h. Three days later, the accounts of lymphocyte subsets increased significantly. The percentages of CD3, CD4, CD8 and NK cells got to stable stage from post-transplantation 10 d, and the absolute accounts of post-transplantation 60 d were higher than those of pre-transplantation, but were still lower than those of HC; The IFN-γ and IL-10 levels of post-transplantation 12 h increased several times and decreased after 3 days. The IL-10 levels in post-transplantation 60 d were still higher than those of HC. CONCLUSION: The absolute accounts of peripheral lymphocyte subsets increased to stable levels from post-transplantation 10 d, but were still lower than those of HC; Post-transplant immune condition was to Th2 polarization.
Authors:
Yan-Qing Feng; Wei-Wei Chen; Jia Liu; Zhen-Hong Liu; Jun-Lian Yang; Ning Yang; Ping Lv; Yuan-Li Mao
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology     Volume:  27     ISSN:  1007-8738     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101139110     Medline TA:  Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi     Country:  -    
Other Details:
Languages:  CHI     Pagination:  787-789     Citation Subset:  -    
Affiliation:
No.302 Hospital of PLA, Beijing 100039, China.
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