Document Detail

Analysis of polyunsaturated fatty acids in newborn sera: a screening tool for atopic disease?
MedLine Citation:
PMID:  8011501     Owner:  NLM     Status:  MEDLINE    
It has been demonstrated that patients with atopic disease have anomalies of fatty acid composition, as a result of altered metabolism or abnormal incorporation of fatty acids into the tissues. In the present study, in 57 newborns 'at risk' for atopic disease, the polyunsaturated fatty acid (PUFA) levels were found to be lower in cord blood in infants who subsequently developed atopic disease than in non-atopics. In all babies, levels of arachidonic acid and dihomo-gamma-linolenic acid in sera at 1 and 3 months of age were lower than those in cord blood. These changes were more marked in children who subsequently developed atopic disease, and in those who, independently of signs and/or symptoms of atopic disease, were formula-fed. A comparison between IgE and PUFA levels revealed no significant differences at any tested time interval. In conclusion, our data suggest that in children 'at risk' for atopy, PUFA levels may be predictive of atopic disease.
E Galli; M Picardo; L Chini; S Passi; V Moschese; O Terminali; F Paone; G Fraioli; P Rossi
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  130     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  752-6     Citation Subset:  IM    
Institute of Pediatrics, University of Rome Tor Vergata, Italy.
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MeSH Terms
8,11,14-Eicosatrienoic Acid / blood
Arachidonic Acid / blood
Asthma / blood
Biological Markers / blood
Breast Feeding
Dermatitis, Atopic / blood
Fatty Acids, Unsaturated / blood*
Fetal Blood / chemistry*
Follow-Up Studies
Hypersensitivity, Immediate / blood,  diagnosis*,  immunology
Immunoglobulin E / analysis
Infant, Newborn
Neonatal Screening / methods*
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Unsaturated; 37341-29-0/Immunoglobulin E; 506-32-1/Arachidonic Acid; 7324-41-6/8,11,14-Eicosatrienoic Acid

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