| Analysis of plasma ghrelin in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II. | |
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MedLine Citation:
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PMID: 22048973 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Ghrelin requires a fatty acid modification for binding to the growth hormone secretagogue receptor. Acylation of the Ser3 residue of ghrelin is essential for its biological activities. We hypothesized that acyl-CoA is the fatty acid substrate for ghrelin acylation. Because serum octanoyl-CoA levels are altered by fatty acid oxidation disorders, we examined circulating ghrelin levels in affected patients.Materials and Methods: Blood levels of acyl (A) and desacyl (D) forms of ghrelin and acylcarnitine of patients with medium chain acyl-CoA dehydrogenase (MCAD) deficiency and glutaric aciduria type II (GA2) were measured.Results: Plasma acyl ghrelin levels and A/D ratios appeared to be elevated in patients with MCAD deficiency or GA2 than in comparison to those in normal subjects. Reverse-phase high-performance liquid chromatography confirmed that n-octanoylated ghrelin levels were elevated in these patients.Conclusion: Changing serum medium-chain acylcarnitine levels may affect circulating acyl ghrelin levels, suggesting that acyl-CoA is the substrate for ghrelin acylation. |
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Authors:
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Takakshi Akamizu; Nobuo Sakura; Yosuke Shigematsu; Go Tajima; Akira Ohtake; Hiroshi Hosoda; Hiroshi Iwakura; Hiroyuki Ariyasu; Kenji Kangawa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-2 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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T Akamizu, The First Department of Medicine, Wakayama Medical University, Wakayama, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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