| Analysis of phospholipase C gene in patients with subarachnoid hemorrhage due to ruptured intracranial saccular aneurysm. | |
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MedLine Citation:
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PMID: 10406008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study is designed to determine whether patients with aneurysmal subarachnoid hemorrhage have mutations in the phospholipase C-delta 1 (PLC-delta 1) gene, which was identified as a gene responsible for hypertension in spontaneously hypertensive rats. Seventy-two cases (31 male and 41 female) with intracranial saccular aneurysms were analyzed. The mean age was 60.1 +/- 11.5 years (mean +/- SD) (range 24-85 years). There were 35 patients (48.6%) with hypertension, 5 (6.9%) with diabetes mellitus, 12 (16.7%) with hyperlipidemia, 8 (11.1%) with ischemic heart disease, and 25 (34.7%) who were active smokers. The location of aneurysm was distributed as follows: 33 (33%) were at anterior cerebral artery, 23 (23%) were at middle cerebral artery, 28 (28%) were at internal carotid artery, and 16 (16%) were at vertebro-basilar artery. Six patients (8.3%) had a family history of intracranial aneurysms. There were 20 patients (27.8%) with multiple aneurysms, and 8 patients (11.1%) with a large or giant aneurysm. The four regions of PLC-delta 1 gene (bases 1099-1271, 1254-1401, 1343-1481, and 1882-2023) where genetic mutations were found in spontaneously hypertensive rats, were screened by PCR-SSCP analysis and their nucleotide sequences of all patients were determined. However, no mutations were detected in all patients. These results suggest that mutations of PLC-delta 1 gene previously implicated in hypertensive factor in rats may not be the case with human patients and therefore may be poorly related with aneurysmal subarachnoid hemorrhage. |
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Authors:
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K Takenaka; H Sakai; H Yamakawa; T Itoh; S Murase; H Yamakawa; A Okumura; Y Nishimura; T Andoh; S Nakashima; Y Nozawa; N Sakai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological research Volume: 21 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 368-72 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Gifu University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aneurysm, Ruptured / complications* DNA Fragmentation / genetics DNA Mutational Analysis DNA Primers / genetics Electrophoresis / methods Female Gene Expression / genetics* Humans Intracranial Aneurysm / complications* Male Middle Aged Point Mutation / genetics Polymorphism, Genetic Subarachnoid Hemorrhage / enzymology*, etiology* Type C Phospholipases / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; EC 3.1.4.-/Type C Phospholipases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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