Document Detail

Analysis of the pharyngoesophageal pressure profile in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  7838549     Owner:  NLM     Status:  MEDLINE    
Treatment of dysphagia resulting from bulbar amyotrophic lateral sclerosis has included cricopharyngeal myotomy for many years but is successful in only a minority of cases. The purpose of this study was to explore the rationale for this procedure with modern manometric techniques. The results of pharyngoesophageal manometry in 13 patients with amyotrophic lateral sclerosis were compared with 13 age- and sex-matched healthy volunteers by Mann-Whitney analysis. There was no significant difference between patients and control subjects in distal esophageal or lower esophageal sphincter motility nor any pressure parameter of pharyngoesophageal motility. Separate analysis of the seven significantly dysphagic subjects showed a significantly reduced upper esophageal sphincter after-contraction amplitude during water and bread swallows in patients than in control subjects. These data suggest that the dysphagia of amyotrophic lateral sclerosis is not due to upper esophageal sphincter spasm and that treatment by cricopharyngeal myotomy may be inappropriate.
G MacDougall; J A Wilson; A Pryde; R Grant
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  112     ISSN:  0194-5998     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  258-61     Citation Subset:  IM    
Department of Otolaryngology, Edinburgh Royal Infirmary, United Kingdom.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications,  physiopathology*
Case-Control Studies
Deglutition / physiology
Deglutition Disorders / etiology,  physiopathology,  surgery
Esophageal Motility Disorders / physiopathology
Esophagogastric Junction / physiopathology
Esophagus / physiopathology*
Middle Aged
Pharyngeal Muscles / physiopathology
Pharynx / physiopathology*
Spasm / physiopathology
Reg. No./Substance:

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