Document Detail


Analysis of pharmaceutical pellets: An approach using near-infrared chemical imaging.
MedLine Citation:
PMID:  21995917     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pharmaceutical pellets are spherical or nearly spherical multi-unit dosage forms designed to optimize pharmacokinetics and pharmacodynamics features of drug release. The distribution of the pharmaceutical ingredients in the layers and core is a very important parameter for appropriate drug release, especially for pellets manufactured by the process of layer gain. Physical aspects of the sample are normally evaluated by Scanning Electron Microscopy (SEM), but it is in many cases unsuitable to provide conclusive chemical information about the distribution of the pharmaceutical ingredients in both layers and core. On the other hand, methods based on spectroscopic imaging can be very promising for this purpose. In this work, a Near-Infrared Chemical Imaging (NIR-CI) method was developed and applied to the analysis of diclophenac sodium pellets. Since all the compounds present in the sample were known in advance, Classical Least Squares (CLS) was used for calculations. The results have shown that the method was capable of providing chemical information about the distribution of the active ingredient and excipients in the core and coating layers and therefore can be complementary to SEM for the pharmaceutical development of pellets.
Authors:
Guilherme P Sabin; Márcia C Breitkreitz; André M de Souza; Patrícia da Fonseca; Lupercio Calefe; Mario Moffa; Ronei J Poppi
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Publication Detail:
Type:  Journal Article     Date:  2011-08-27
Journal Detail:
Title:  Analytica chimica acta     Volume:  706     ISSN:  1873-4324     ISO Abbreviation:  Anal. Chim. Acta     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370534     Medline TA:  Anal Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
Affiliation:
Institute of Chemistry, University of Campinas, P.O. Box 6154, 13084-971 Campinas, SP, Brazil.
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