| Analysis of phagosomal proteomes: from latex-bead to bacterial phagosomes. | |
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MedLine Citation:
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PMID: 21080496 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Phagosomal proteome characterization has contributed significantly to the understanding of host-pathogen interaction and the mechanism of infectious diseases caused by intracellular bacteria. The latex bead-containing phagosome has been widely used as a model system to study phagosomal proteomes at a global level. In contrast, the study of bacteria-containing phagosomes at a similar level has just begun. A number of intracellular microbial species are studied for their proteomes during the invasion of a host, providing insight into their metabolic adaptation in host cells and interaction with host-cell antimicrobial environments. In this review, we attempt to summarize the most recent advancements in the proteomic study of microbial phagosomes, especially those originating from mouse or human cells. We also briefly describe the proteomics of latex bead-containing phagosomes because they are often used as model phagosomes for study. We provide descriptions on major biological and technological components in phagosomal proteome studies. We also discuss the role of phagosomal proteome study in the broader horizon of systems biology and the technological challenges in phagosomal proteome characterization. |
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Authors:
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Qingbo Li; Chinnaswamy Jagannath; Prahlad K Rao; Christopher R Singh; Giovanni Lostumbo |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proteomics Volume: 10 ISSN: 1615-9861 ISO Abbreviation: Proteomics Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092707 Medline TA: Proteomics Country: Germany |
Other Details:
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Languages: eng Pagination: 4098-116 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, Chicago, IL 60607, USA. qkli@uic.edu |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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