Document Detail

Analysis of the periodontal microbiota in childhood-type hypophosphatasia.
MedLine Citation:
PMID:  16875876     Owner:  NLM     Status:  MEDLINE    
Seven patients with childhood-type hypophosphatasia and healthy control subjects were analysed for microbiological and clinical evidence of periodontitis. The bacterial composition of the subgingival plaque was analysed by 16S rRNA gene cloning and sequencing, DNA-DNA hybridisation with specific probes, and specific PCR. With the exception of the genus Veillonella and the species Eikenella corrodens, no differences between the cohorts in the composition of bacterial orders, families, genera, and species were observed. Accordingly, patients showed only slightly more bleeding on probing (BOP), and slightly higher periodontal probing depth (PPD) values than controls. Although this pilot study did not have the power to assess the prevalence of periodontitis in HP, we suggest that most paediatric patients suffering from HP harbour a subgingival microbiota, which is comparable to that of the healthy population.
Giuseppe Valenza; Stefan Burgemeister; Hermann Girschick; Christoph Schoen; Simone Veihelmann; Annette Moter; Vesna Haban; Ulrich Vogel; Ulrich Schlagenhauf
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-27
Journal Detail:
Title:  International journal of medical microbiology : IJMM     Volume:  296     ISSN:  1438-4221     ISO Abbreviation:  Int. J. Med. Microbiol.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898849     Medline TA:  Int J Med Microbiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  493-500     Citation Subset:  IM    
Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Strasse 2/E1, D-97080 Würzburg, Germany.
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MeSH Terms
Bacteria / classification*,  genetics,  isolation & purification*
Cohort Studies
DNA, Bacterial / chemistry,  genetics
DNA, Ribosomal / chemistry,  genetics
Dental Plaque / microbiology*
Genes, rRNA / genetics
Hypophosphatasia / complications*
Molecular Sequence Data
Nucleic Acid Hybridization
Periodontal Index
Periodontal Pocket / pathology
Periodontitis / microbiology*
RNA, Bacterial / genetics
RNA, Ribosomal, 16S / genetics
Sequence Analysis, DNA
Sequence Homology, Nucleic Acid
Reg. No./Substance:
0/DNA, Bacterial; 0/DNA, Ribosomal; 0/RNA, Bacterial; 0/RNA, Ribosomal, 16S

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